TSLP (R127A, R130A) Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-273-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
TSLP
Application Note:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 41.6 kDa. The protein migrates as 50-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
Background References:
- Segawa R., et al., 2017, J. Dermatol. Sci. S0923-1811:31012-31015.
- Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106.
- Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.
Buffer:
PBS, pH7.4
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
85480
NCBI Official Name:
thymicstromallymphopoietin
NCBI Official Symbol:
TSLP
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
41.6 kDa
Protein Accession #:
NP_149024.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q969D9