GUCY2C / Guanylyl cyclase C Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-208-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-100 kD under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
Background References:
- Magee MS, et al. Cancer Immunol Res. 2018. 6(5):509-516.
- Li P, et al. Cancer Res. 2017. 77(18):5095-5106.
- Arshad N, et al. J Biol Chem. 2013. 288(6):3907-17.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
49.0 kDa
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells