Siglec-2 / CD22 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-455-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD22,SIGLEC2,BL-CAM,SIGLEC-2,Siglec2,SIGLEC2FLJ22814
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 78.3 kDa. The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Background References:
- Hatta Y., et al., 1999, Immunogenetics 49:280-286.
- Doody G.M., et al., 1995, Science 269:242-244.
- Tuscano J.M., et al., 1996, Eur. J. Immunol. 26:1246-1252.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
12483
NCBI Official Name:
CD22 antigen
NCBI Official Symbol:
Cd22
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
78.3 kDa
Protein Accession #:
P35329.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P35329