CD38 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-441-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD38,T10,cADPr hydrolase 1
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
Background References:
- Orciani M., et al., 2008, J. Cell. Biochem. 105 (3): 905?12.
- Nata K., et al., 1997, Gene 186 (2): 285?92.
- Malavasi F., et al., 2008, Physiol. Rev. 88 (3): 841?86.
Buffer:
50 mM MES, 100 mM NaCl, pH6.5
Fusion Tag:
His Tag
NCBI Gene ID #:
12494
NCBI Official Name:
CD38 antigen
NCBI Official Symbol:
Cd38
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
31.7 kDa
Protein Accession #:
NP_031672.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P56528