Flt-3 / Flk-2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-284-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Background References:
- Zheng R,et al. 2011. Oncogene. 30(38):4004-14.
- Mizuki M, et al. 2000. Blood. 96(12):3907-14.
- Small D, et al. 1994. Proc Natl Acad Sci U S A. 91(2):459-63.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
14255
NCBI Official Name:
FMS-liketyrosinekinase3
NCBI Official Symbol:
Flt3
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
59.9 kDa
Protein Accession #:
NP_034359.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q00342