ICOS / CD278 (C137S, C138S) Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-360-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ICOS,CD278,AILIM,Inducible T-cell costimulator
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Background References:
- Hutloff A., et al., 1999, Nature 397:263-266.
- Tezuka K., et al., 2000, Biochem. Biophys. Res. Commun. 276:335-345.
- Beier K.C., et al., 2000, Eur. J. Immunol. 30:3707-3717.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
54167
NCBI Official Name:
inducible T cell co-stimulator
NCBI Official Symbol:
Icos
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
15.7 kDa
Protein Accession #:
NP_059508.2(C137S,C138S)
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9WVS0