PD-L1 / B7-H1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-345-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Rabbit
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.1 kDa. The protein migrates as 32-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Background References:
- Dong H., et al., 1999, Nat. Med. 5:1365-1369.
- Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.
- Nishimura H., et al., 2001, Trends?in?Immunology?22:265.?
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
100357106
NCBI Official Name:
CD274 molecule
NCBI Official Symbol:
CD274
NCBI Organism:
Oryctolagus cuniculus
Physical State:
Lyophilized
Predicted Molecular Weight:
27.1 kDa
Protein Accession #:
XP_008253343.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells