SARS-CoV-2 (COVID-19) S2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-184-0.2mg | 0.2mg | £1,257.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: SARS-CoV-2
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Dry ice
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
Spike,S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2,COVID-19
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.0 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Background References:
- Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.
- Benvenuto D, et al. J Med Virol. 2020.
- Chang CY, et al. AMB Express. 2020. 10(1):20.
Buffer:
20 mM PB, 300 mM NaCl, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
43740568
NCBI Official Name:
surfaceglycoprotein
NCBI Official Symbol:
S
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
60.0 kDa
Protein Accession #:
QHD43416.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P0DTC2