Rhesus macaque CD28 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-530-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species:
- Cynomolgus Monkey
- Human
- Rhesus Macaque
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD28,Tp44
Application Note:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.0 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Background References:
- Evans E.J., et al., 2005, Nat. Immunol. 6:271-279.
- Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46.
- Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
Buffer:
50 mM Tris, 100 mM Glycine, pH7.5
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
940
NCBI Official Name:
CD28 molecule
NCBI Official Symbol:
CD28
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
42.0 kDa
Protein Accession #:
NP_006130.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P10747