Rhesus macaque Properdin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-237-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Rhesus Macaque
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
Properdin,Complement factor P,CFP,PFC
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates(PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.
Background References:
- Blatt AZ, et al. 2016. J Immunol. 196(11):4671-4680.
- Pathan S, et al. 2016. Immunol Rev. 274(1):172-190.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
707386
NCBI Official Name:
complementfactorproperdin
NCBI Official Symbol:
CFP
NCBI Organism:
Macaca mulatta
Physical State:
Lyophilized
Predicted Molecular Weight:
50.6 kDa
Protein Accession #:
XP_014982784.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells