Rhesus macaque Glypican 2 / GPC2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-253-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Rhesus Macaque
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
Glypican 2,GPC2
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 55-95 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Background:
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
Background References:
- Herndon ME, et al. 1999. Glycobiology. 9(2):143-55.
- Li N, et al. 2017. Proc Natl Acad Sci U S A. 114(32):E6623-E6631.
- Bosse KR, et al. 2017. Cancer Cell. 32(3):295-309.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
711426
NCBI Official Name:
glypican2
NCBI Official Symbol:
GPC2
NCBI Organism:
Macaca mulatta
Physical State:
Lyophilized
Predicted Molecular Weight:
59.9 kDa
Protein Accession #:
XP_001103286
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells