Complement Component C5a Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-356-0.1mg | 0.1mg | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: E.coli
Regulatory Status: RUO
Target Species: Cynomolgus Monkey
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
C5a,Complement Component 5a
Application Note:
This protein carries no "tag". The protein has a calculated MW of 8.4 kDa. The protein migrates as 11 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
Background References:
- Gerard, C. and N.P. Gerard, 1994, Annu. Rev. Immunol.12:775.
- Monk, PN. et al., 2007, British Journal of Pharmacology. 152: 429-48.
- Reis ES, et al., 2011,Brain Behav Immun. Apr 23.
- Bergseth G,et al., 2011, Ann Thorac Surg., 91(2):527-33.
Buffer:
PBS, pH7.4
Fusion Tag:
Tag Free
NCBI Gene ID #:
102125658
NCBI Official Name:
complement C5
NCBI Official Symbol:
C5
NCBI Organism:
Macaca fascicularis
Physical State:
Lyophilized
Predicted Molecular Weight:
8.4 kDa
Protein Accession #:
XP_015292262.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
E. coli