Tau-441 / 2N4R Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-378-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: E.coli
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.
Background References:
- Yoshida H, et al. 2012. J. Neurochem. 120:165-176.
- Alonso A., et al. 2001.Proc. Natl. Acad. Sci. U.S.A.98 (12): 6923?8
Buffer:
50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
4137
NCBI Official Name:
microtubule associated protein tau
NCBI Official Symbol:
MAPT
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
47.9 kDa
Protein Accession #:
NP_005901.2
Purity:
>90% as determined by reduced SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P10636