GDF-15 / MIC-1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-261-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: E.coli
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
GDF15,GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,NRG-1
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.2 kDa. the protein migrates as 16-17 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).
Background:
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
Background References:
- Bootcov MR., et al. 1997, Proc Natl Acad Sci U S A., 94(21), 11514-9.
- Adela R., et al. 2015, J Diabetes Res., 2015, 490842.
Buffer:
60% ACN, 0.085% TFA
Fusion Tag:
His Tag
NCBI Gene ID #:
9518
NCBI Official Name:
growthdifferentiationfactor15
NCBI Official Symbol:
GDF15
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
14.2 kDa
Protein Accession #:
NP_004855.2
Purity:
>90% as determined by reduced SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q99988