Vitronectin / VTN Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-248-0.1mg | 0.1mg | £373.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: E.coli
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor
Application Note:
This protein carries no "tag". The protein has a calculated MW of 43.2 kDa. The protein migrates as 48-50 kDa under reducing (R) condition (SDS-PAGE).
Background:
Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Background References:
- Kohler S, et al. 2015 Thromb Haemost. 113:125-42. (2) Salazar-Pel?ez LM, et al. 2015. PLoS One. 10(3):e0119717. (3) Paulsson M, et al. 2015. J Cyst Fibros. 14(5):600-7.
Buffer:
20 mM Tris-HCl, Arginine, pH8.0
Fusion Tag:
Tag Free
NCBI Gene ID #:
7448
NCBI Official Name:
vitronectin
NCBI Official Symbol:
VTN
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
43.2 kDa
Protein Accession #:
NP_000629.3
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P04004