Clevudine
| Code | Size | Price |
|---|
| PSI-11-076-50mg | 50mg | £368.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice or RT
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
Levovir; L-FMAU; 2'-Fluoro-5-methyl-L-arabinofuranosyl-uracil
Background:
Clevudine is a synthetic pyrimidine nucleoside analog antiviral agent with activity against hepatitis B virus (HBV) and Epstein-Barr virus (EBV).
Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase and reverse transcriptase, consequently blocking the viral replication. It also blocks the DNA supply of the virus into the nucleus, reducing the amount of cccDNA by 20-100 times.
Potentially useful for the treatment of the SARS-CoV-2 (COVID-19) infection, acting as a potent inhibitor of the RdRp protein.
CAS:
163252-36-6
Formula:
C10H13FN2O5
Identity:
Determined by 1H-NMR.
InChi Key:
GBBJCSTXCAQSSJ-XQXXSGGOSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
260.2
Purity:
greater than or equal to 98% (HPLC)
Smiles:
O[C@H]1[C@H](CO)O[C@]([H])(N2C=C(C)C(NC2=O)=O)[C@@H]1F
Solubility:
Soluble in water (30mg/ml) or DMSO (20mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in water (30mg/ml) or DMSO (20mg/ml).