Boceprevir
| Code | Size | Price |
|---|
| PSI-11-075-50mg | 50mg | £409.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice or RT
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
Victrelis; EBP 520; SCH 503034
Background:
The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM.
Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13?M).
CAS:
394730-60-0
Formula:
C27H45N5O5
Identity:
Determined by 1H-NMR.
InChi Key:
LHHCSNFAOIFYRV-DOVBMPENSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
519.7
Purity:
greater than or equal to 95% (NMR)
Smiles:
[H][C@]1(C2(C)C)[C@]2([H])CN(C([C@H](C(C)(C)C)NC(NC(C)(C)C)=O)=O)[C@]1([H])C(NC(CC3CCC3)C(C(N)=O)=O)=O
Solubility:
Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).