Forskolin
| Code | Size | Price |
|---|
| CDX-F0167-M010 | 10 mg | £132.00 |
Quantity:
| CDX-F0167-M025 | 25 mg | £267.00 |
Quantity:
| CDX-F0167-M050 | 50 mg | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
Boforsin; Colforsin; Coleonol; NSC 357088; NSC 375489; HL 362; L 75-1362B
Appearance:
White to off-white powder.
CAS:
66575-29-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChiKey:
OHCQJHSOBUTRHG-KGGHGJDLSA-N
Long Description:
Chemical. CAS: 66575-29-9. Formula: C22H34O7. MW: 410.5. Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer?s disease symptoms and has also shown a number of antitumor effects.
MDL:
MFCD00082317
Molecular Formula:
C22H34O7
Molecular Weight:
410.5
Package Type:
Vial
Product Description:
Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer?s disease symptoms and has also shown a number of antitumor effects.
Purity:
>98% (HPLC)
SMILES:
C=C[C@](C1)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@@]2(O)C1=O
Solubility Chemicals:
Soluble in DMSO, DMF or ethanol.
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) H. Metzger & E. Lindner; Arzneimittelforschung 31, 1248 (1981) | (2) K.B. Seamon & J.W. Daly; J. Cyclic Nucleotide Res. 7, 201 (1981) | (3) N.J. de Souza, et al.; Med. Res. Rev. 3, 201 (1983) | (4) H.G. Joost & H.J. Steinfelder; Mol. Pharmacol. 31, 279 (1987) | (5) A. Laurenza, et al.; TIPS 10, 442 (1989) (Review) | (6) M.L. Aylwin & M.M. White; Mol. Pharmacol. 41, 908 (1992) | (7) P.J. Scarpace & M. Matheny; Pflugers Arch. 431, 388 (1996) | (8) P.A. Insel & R.S. Ostrom; Cell Mol. Neurobiol. 23, 305 (2003) | (9) N. Canu, et al.; J. Neurochem. 92, 1228 (2005) | (10) H. Yamanaka, et al.; Mol. Med. Rep. 3, 133 (2010) | (11) R.H. Alasbahi & M.F. Melzig; Pharmazie 67, 5 (2012) (Review) | (12) V.D. Wagh, et al.; J. Postgrad. Med. 58, 199 (2012) (Review) | (13) B.A. Owona, et al.; J. Neuropathol. Exp. Neurol. 75, 618 (2016) | (14) L. Sapio, et al.; J. Cell Physiol. 232, 922 (2017) (Review)