Ononin
| Code | Size | Price |
|---|
| CDX-O0086-M001 | 1 mg | £78.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
Formononetin 7-O-beta-D-glucopyranoside; Ononoside
Appearance:
White powder.
CAS:
486-62-4
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1
InChiKey:
MGJLSBDCWOSMHL-MIUGBVLSSA-N
Long Description:
Chemical. CAS: 486-62-4. Formula: C22H22O9. MW: 430.40. Ononin is a glycoside isoflavone that has been found in soybeans. It has anti-inflammatory activity by inhibiting the NF-kappaB and MAPK pathways and neuroprotective properties. Ononin inhibits LPS-induced production of nitrite, prostaglandin E2 and the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha by RAW 264.7 macrophages. It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells.
MDL:
MFCD00017464
Molecular Formula:
C22H22O9
Molecular Weight:
430.4
Package Type:
Vial
Product Description:
Ononin is a glycoside isoflavone that has been found in soybeans. It has anti-inflammatory activity by inhibiting the NF-kappaB and MAPK pathways and neuroprotective properties. Ononin inhibits LPS-induced production of nitrite, prostaglandin E2 and the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha by RAW 264.7 macrophages. It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells.
Purity:
>98% (HPLC)
SMILES:
O[C@H]1[C@H](OC2=CC=C(C(C(C3=CC=C(OC)C=C3)=CO4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
Solubility Chemicals:
Soluble in DMSO (10mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) D. Yu, et al.; J. Ethnopharmacol. 98, 89 (2005) | (2) L. Dong, et al.; Mol. Immunol. 83, 46 (2017) | (3) T. Wang, et al.; J. Sci. Food Agric. 98, 2043 (2018) | (4) Y. Yu, et al.; Pharmacol. Res. 145, 104248 (2019) | (5) L. Luo, et al.; Metabolomics 15, 153 (2019)