Honokiol

5,3'-Diallyl-2,4'-dihydroxybiphenyl; NSC 293100

Light brown powder.

35354-74-6

32160000

liquid

Protect from light and moisture.

InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

FVYXIJYOAGAUQK-UHFFFAOYSA-N

Chemical. CAS: 35354-74-6. Formula: C18H18O2. MW: 266.33. Honokiol is a natural product derived from parts of the plant M. grandiflora used in Oriental herbal medicine. It is a lignan with diverse biological activities, including anticancer, neuroprotective, antithrombotic, anti-inflammatroy, antioxidant, antiviral, analgesic, antimicrobial, metabolic and GABA-modulating properties. Honokiol exerts broad-range anticancer activity in vitro and in vivo such as induction of cell cycle arrest and apoptosis, inhibition of epithelial-mesenchymal transition, inhibiting cell migration, invasion, and metastasis, as well as inducing anti-angiogenesis activity. Honokiol has neuroprotective effects based on its potent antioxidant activity, blockade of glutamate receptors and reduction in neuroinflammation. Honokiol also blocks inflammatory factor production in glial cells through the inhibition on NF-kappa activation. It protects against lipid peroxidation by interfering with ROS production and migration. It regulates gamma-aminobutyric acid (GABA) A receptors and it also prevents platelet aggregation. Honokiol has been shown to inhibit hepatitis C virus (HCV) infection in vitro and described as a non-adipogenic PPARgamma agonist.

MFCD00016674

C18H18O2

266.33

Vial

Honokiol is a natural product derived from parts of the plant M. grandiflora used in Oriental herbal medicine. It is a lignan with diverse biological activities, including anticancer, neuroprotective, antithrombotic, anti-inflammatroy, antioxidant, antiviral, analgesic, antimicrobial, metabolic and GABA-modulating properties. Honokiol exerts broad-range anticancer activity in vitro and in vivo such as induction of cell cycle arrest and apoptosis, inhibition of epithelial-mesenchymal transition, inhibiting cell migration, invasion, and metastasis, as well as inducing anti-angiogenesis activity. Honokiol has neuroprotective effects based on its potent antioxidant activity, blockade of glutamate receptors and reduction in neuroinflammation. Honokiol also blocks inflammatory factor production in glial cells through the inhibition on NF-kappa activation. It protects against lipid peroxidation by interfering with ROS production and migration. It regulates gamma-aminobutyric acid (GABA) A receptors and it also prevents platelet aggregation. Honokiol has been shown to inhibit hepatitis C virus (HCV) infection in vitro and described as a non-adipogenic PPARgamma agonist.

>98% (HPLC)

OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (30mg/ml).

Plant

Non-hazardous

Natural Products/Extracts

12352200

Stable for at least 2 years after receipt when stored at +4°C.