Lupeol
| Code | Size | Price |
|---|
| CDX-L0128-M025 | 25 mg | £84.00 |
Quantity:
| CDX-L0128-M100 | 100 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
beta-Viscol; 20(29)-Lupen-3beta-ol; 3beta-Hydroxy-20(29)-lupene; Clerodol; Fagarasterol; Lupenol; Monogynol B; NSC 90487
Appearance:
White Powder.
CAS:
545-47-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1
InChiKey:
MQYXUWHLBZFQQO-QGTGJCAVSA-N
Long Description:
Chemical. CAS: 545-47-1. Formula: C30H50O. MW: 426.72. Lupeol, is a dietary triterpene found in certain fruits, vegetables, and medicinal plants. Lupeol has been shown tohave a broad range of activities, including antioxidant, anti-inflammatory, anticancer, antihyperglycemic, antidyslipidemic, antimutagenic, anti-diabetic, anti-asthma, antiprotozoal, antimicrobial, cardioprotective, hepatoprotective, nephroprotective and neuroprotective properties. It is a multi-target agent targeting proteins such as alpha-glucosidase, alpha-amylase, protein tyrosine phosphatase 1B (PTP 1B) and TCA cycle enzymes and targeting pathways such as IL-1 receptor-associated kinase-mediated toll-like receptor 4 (IRAK-TLR4), Bcl-2 family, nuclear factor kappa B (NF-kappa), phosphatidylinositol-3-kinase (PI3-K)/Akt and Wnt/beta-catenin signaling pathways.
MDL:
MFCD00017351
Molecular Formula:
C30H50O
Molecular Weight:
426.72
Package Type:
Vial
Product Description:
Lupeol, is a dietary triterpene found in certain fruits, vegetables, and medicinal plants. Lupeol has been shown tohave a broad range of activities, including antioxidant, anti-inflammatory, anticancer, antihyperglycemic, antidyslipidemic, antimutagenic, anti-diabetic, anti-asthma, antiprotozoal, antimicrobial, cardioprotective, hepatoprotective, nephroprotective and neuroprotective properties. It is a multi-target agent targeting proteins such as alpha-glucosidase, alpha-amylase, protein tyrosine phosphatase 1B (PTP 1B) and TCA cycle enzymes and targeting pathways such as IL-1 receptor-associated kinase-mediated toll-like receptor 4 (IRAK-TLR4), Bcl-2 family, nuclear factor kappa B (NF-kappa), phosphatidylinositol-3-kinase (PI3-K)/Akt and Wnt/beta-catenin signaling pathways.
Purity:
>97% (HPLC)
SMILES:
C[C@@]12CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@@]1([H])[C@H](C(C)=C)CC2
Solubility Chemicals:
Soluble in DMSO (1mg/ml), DMF (1mg/ml) or ethanol (1mg/ml). Insoluble in water.
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) S. Sunitha, et al.; Fitoterapia 72, 516 (2001) | (2) M.A. Fernandez, et al.; J. Pharm. Pharmacol. 53, 1533 (2001) | (3) Y.J. You, et al.; Phytother. Res. 17, 341 (2003) | (4) M. Saleem, e al.; Oncogene 23, 5203 (2004) | (5) J. Fotie, et al.; J. Nat. Prod. 69, 62 (2006) | (6) M. Saleem, et al.; Clin. Cancer Res. 14, 2119 (2008) | (7) M. Saleem, et al.; Carcinogenesis 30, 808 (2009) | (8) K. Papi Reddy, et al.; Bioorg. Med. Chem. Lett. 19, 4463 (2009) | (9) R.S. Tarapore, et al.; Carcinogenesis 31, 1844 (2010) | (10) H.R. Siddique, et al.; Clin. Cancer Res. 17, 5379 (2011) | (11) H.R. Siddique & M. Saleem; Life Sci. 88, 285 (2011) (Review) | (12) F.S. Tsai, et al.; Adv. Exp. Med. Biol. 929, 145 (2016) (Review) | (13) V.R. Machado, et al.; Nat. Prod. Res. 32, 275 (2018) | (14) A. Malik, et al.; Drug Des. Devel. Ther. 13, 1501 (2019)