Apigenin 7-glucoside
| Code | Size | Price |
|---|
| CDX-A0568-M005 | 5 mg | £59.00 |
Quantity:
| CDX-A0568-M010 | 10 mg | £96.00 |
Quantity:
| CDX-A0568-M025 | 25 mg | £181.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Apigetrin; Cosmosiin; 4',5,7-Trihydroxyflavone 7-glucoside; 7-O-beta-D-Glucopyranosylapigenin; Apigenin-7-O-beta-D-glucoside; NSC 407303
Appearance:
Light yellow powder.
CAS:
578-74-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C21H20O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-7,16,18-24,26-28H,8H2/t16-,18-,19+,20-,21-/m1/s1
InChiKey:
KMOUJOKENFFTPU-QNDFHXLGSA-N
Long Description:
Chemical. CAS: 578-74-5. Formula: C21H20O10. MW: 432.38. Apigenin 7-glucoside is a flavonoid with anti-inflammatory, antioxidant, anticancer, anti-adipogenic and anxiolytic activities. It has been shown to inhibit LPS-induced nitric oxide production in RAW 264.7 cells or have hepatoprotective activity due to it's antioxidant activities, acting as scavengers of ROS. Apigenin 7-glucoside has been shown to have anti-proliferative activity, possible through cell cycle inhibition and consequently induce apoptosis. it also has the ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside has shown neuroprotective effects possibly by inhibiting neuroinflammation and its antioxidant activity. Apigenin-7-O-glucoside inhibits adipogenesis of 3T3-L1 preadipocytes at early stage of adipogenesis at high concentrations, by downregulating PPARgamma and CEBP-alpha.
MDL:
MFCD00016787
Molecular Formula:
C21H20O10
Molecular Weight:
432.38
Package Type:
Vial
Product Description:
Apigenin 7-glucoside is a flavonoid with anti-inflammatory, antioxidant, anticancer, anti-adipogenic and anxiolytic activities. It has been shown to inhibit LPS-induced nitric oxide production in RAW 264.7 cells or have hepatoprotective activity due to it's antioxidant activities, acting as scavengers of ROS. Apigenin 7-glucoside has been shown to have anti-proliferative activity, possible through cell cycle inhibition and consequently induce apoptosis. it also has the ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside has shown neuroprotective effects possibly by inhibiting neuroinflammation and its antioxidant activity. Apigenin-7-O-glucoside inhibits adipogenesis of 3T3-L1 preadipocytes at early stage of adipogenesis at high concentrations, by downregulating PPARgamma and CEBP-alpha.
Purity:
>97% (HPLC)
SMILES:
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(OC(C3=CC=C(O)C=C3)=CC4=O)=C4C(O)=C2)[C@@H]1O
Solubility Chemicals:
Soluble in DMSO (5mg/ml) or DMF.
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) J. Fuchs & R. Milbradt; Arzneimittelforschung 43, 370 (1993) | (2) Q.S. Zheng, et al.; Biomed. Environ. Sci. 18, 65 (2005) | (3) E. Nakazaki, et al.; Eur. J. Nutr. 52, 25 (2013) | (4) D. Kumar & Z.A. Bhat; Phytomedicine 21, 1010 (2014) | (5) N. Nasr Bouzaiene, et al.; Life Sci. 144, 80 (2016) | (6) H.S. Lim, et al.; J. Med. Food 19, 1032 (2016) | (7) Q. Sun, et al.; BBRC 498, 164 (2018) | (8) F. Hadrich & S. Sayadi; Lipids Health Dis. 17, 95 (2018) | (9) H. Guo, et al.; Biomed. Pharmacother. 109, 1978 (2019)