Tetra-O-methylscutellarein
| Code | Size | Price |
|---|
| CDX-M0514-M001 | 1 mg | £157.00 |
Quantity:
| CDX-M0514-M005 | 5 mg | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Scutellarein tetramethyl ether; 5-Methoxysalvigenin; 4',5,6,7-Tetramethoxyflavone; NSC53908
Appearance:
White to yellow powder.
CAS:
1168-42-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C19H18O6/c1-21-12-7-5-11(6-8-12)14-9-13(20)17-15(25-14)10-16(22-2)18(23-3)19(17)24-4/h5-10H,1-4H3
InChiKey:
URSUMOWUGDXZHU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1168-42-9. Formula: C19H18O6. MW: 342.3. Tetra-O-methylscutellarein is a bioactive component of Siam weed extract. It exhibits anti-inflammatory activity through inhibition of the NF-kappaB pathway. It suppressed IkappaB kinase complex alpha/beta (IKKalpha/beta) and Inhibitory-kappa-B-alpha (IkappaBalpha), inhibiting p65 translocation and thereby suppressing COX-2 and iNOS expression. This compound is modulating bacterial resistance to antimicrobial drugs most probably via efflux pump inhibition. It also showed anti-mutagenic activity.
MDL:
MFCD00017442
Molecular Formula:
C19H18O6
Molecular Weight:
342.3
Package Type:
Vial
Product Description:
Tetra-O-methylscutellarein is a bioactive component of Siam weed extract. It exhibits anti-inflammatory activity through inhibition of the NF-kappaB pathway. It suppressed IkappaB kinase complex alpha/beta (IKKalpha/beta) and Inhibitory-kappa-B-alpha (IkappaBalpha), inhibiting p65 translocation and thereby suppressing COX-2 and iNOS expression. This compound is modulating bacterial resistance to antimicrobial drugs most probably via efflux pump inhibition. It also showed anti-mutagenic activity.
Purity:
>95% (HPLC)
SMILES:
O=C(C=C(C1=CC=C(OC)C=C1)O2)C3=C2C=C(OC)C(OC)=C3OC
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or chloroform.
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) M. Miyazawa, et al.; J. Agric. Food Chem. 47, 5239 (1999) | (2) G.L. Maia, et al.; Molecules 16, 4828 (2011) | (3) H. Pandith, et al.; J. Ethnopharmacol. 147, 434 (2013)