Hederacoside C
| Code | Size | Price |
|---|
| CDX-H0299-M050 | 50 mg | £96.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
Hederasaponin C; Kalopanaxsaponin B
Appearance:
White powder.
CAS:
14216-03-6
Class:
6.1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302
InChi:
InChI=1S/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27-,28-,29+,30+,31+,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1
InChiKey:
RYHDIBJJJRNDSX-MCGLQMIESA-N
Long Description:
Chemical. CAS: 14216-03-6. Formula: C59H96O26. MW: 1221.38. Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-alpha, IL-1beta, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-kappa (p65 and IkappaBalpha) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and IkappaBalpha.
MDL:
MFCD00198062
Molecular Formula:
C59H96O26
Molecular Weight:
1221.38
Package Type:
Vial
PG:
III
Product Description:
Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-alpha, IL-1beta, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-kappa (p65 and IkappaBalpha) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and IkappaBalpha.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
O=C(O[C@H](O[C@@H]1CO[C@H](O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]2O[C@@](O[C@H]3C)([H])[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]1O)[C@@]4(CC5)CC[C@]6(C)C([C@]4([H])CC5(C)C)=CC[C@@]7([H])[C@@]6(C)CC[C@]8([H])[C@]7(C)CC[C@H](O[C@@](OC[C@@H]9O)([H])[C@]([C@H]9O)([H])O[C@H](O[C@H]%10C)[C@H](O)[C@H](O)[C@H]%10O)[C@@]8(C)CO
Solubility Chemicals:
Soluble in DMSO (5mg/ml), DMF (15mg/ml) or ethanol (10mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UN Nummer:
2811
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) A. Gepdiremen, et al.; Phytomedicine 12, 440 (2005) | (2) E.H. Joh, et al.; Cell Immunol. 279, 103 (2012) | (3) E.H. Joh, et al.; Phytother. Res. 26, 546 (2012) | (4) M. Akhtar, et al.; Inflammation (Epub ahead of print) (2019) | (5) M. Akhtar, et al.; Microb. Pathog. 137, 103767 (2019)