Hyperoside
| Code | Size | Price |
|---|
| CDX-H0298-M025 | 25 mg | £255.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
3,3',4',5,7-Pentahydroxyflavone 3-D-galactoside; Hyperin; Quercetin 3-D-galactoside; NSC 407304
Appearance:
Yellow powder.
CAS:
482-36-0
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1
InChiKey:
OVSQVDMCBVZWGM-DTGCRPNFSA-N
Long Description:
Chemical. CAS: 482-36-0. Formula: C21H20O12. MW: 464.38. Hyperoside is a 3-O-galactoside of quercetin that can be found in a wide range of plants. It shows diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, antihypoglycemic and antiadipogenic, antibacterial and anticancer properties. It has powerful antioxidant action through its ability to scavenge free radicals. It inhibits the NF-kappaB signaling pathway. Hyperoside selectively interrupted NLRC4 and AIM2 inflammasome activation but did not alter cytokine expression. The quorum sensing-inhibiting effect of hyperoside may lead to a reduction in biofilm formation in P. aeruginosa. Honokiol exerts broad-range anticancer activity, such as induction of apoptosis and autophagy and inhibition of cell proliferation. Hyperoside has a beneficial effect on the prevention and treatment of obesity.
MDL:
MFCD00016933
Molecular Formula:
C21H20O12
Molecular Weight:
464.38
Package Type:
Vial
Product Description:
Hyperoside is a 3-O-galactoside of quercetin that can be found in a wide range of plants. It shows diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, antihypoglycemic and antiadipogenic, antibacterial and anticancer properties. It has powerful antioxidant action through its ability to scavenge free radicals. It inhibits the NF-kappaB signaling pathway. Hyperoside selectively interrupted NLRC4 and AIM2 inflammasome activation but did not alter cytokine expression. The quorum sensing-inhibiting effect of hyperoside may lead to a reduction in biofilm formation in P. aeruginosa. Honokiol exerts broad-range anticancer activity, such as induction of apoptosis and autophagy and inhibition of cell proliferation. Hyperoside has a beneficial effect on the prevention and treatment of obesity.
Purity:
>98% (HPLC)
SMILES:
O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)=C1O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O
Solubility Chemicals:
Soluble in DMSO (10mg/ml) or DMF (10mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) M.J. Piao, et al.; Biochim. Biophys. Acta 1780, 1448 (2008) | (2) S.J. Kim, et al.; Am. J. Chin. Med. 39, 171 (2011) | (3) K.W. Zeng, et al.; Eur. J. Pharmacol. 672, 45 (2011) | (4) N. Zhang, et al.; PLoS One 9, e98973 (2014) | (5) S.K. Ku, et al.; Inflammation 38, 784 (2015) | (6) T. Fu, et al.; Acta Pharmacol. Sin. 37, 505 (2016) | (7) P. Lu; Biomed. Pharmacother. 82, 216 (2016) | (8) H. Ahn & G.S. Lee; Phytomedicine 24, 77 (2017) | (9) Y. Sun, et al.; Exp. Ther. Med. 14, 1647 (2017) | (10) Y. Zhang, et al.; Int. J. Mol. Med. 41, 77 (2018) | (11) M. Berkoz; Acta Endocrinol. 15, 165 (2019)