Glycitein
| Code | Size | Price |
|---|
| CDX-G0213-M010 | 10 mg | £89.00 |
Quantity:
| CDX-G0213-M025 | 25 mg | £157.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 4',7-Dihydroxy-6-methoxyisoflavone; Glycetein
Appearance:
White powder.
CAS:
40957-83-3
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C16H12O5/c1-20-15-6-11-14(7-13(15)18)21-8-12(16(11)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
InChiKey:
DXYUAIFZCFRPTH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 40957-83-3. Formula: C16H12O5. MW: 284.26. Glycitein is an O-methylated isoflavone. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro. It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor. It has also been shown to have antioxidant properties and to inhibit c-Jun N-terminal kinase. It also has been shown to inhibit glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression, or to induce reactive oxygen species-dependent apoptosis and G0/G1 cell cycle arrest through the MAPK/STAT3/NF-kappa pathway in human gastric cancer cells.
MDL:
MFCD00016679
Molecular Formula:
C16H12O5
Molecular Weight:
284.26
Package Type:
Vial
Product Description:
Glycitein is an O-methylated isoflavone. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro. It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor. It has also been shown to have antioxidant properties and to inhibit c-Jun N-terminal kinase. It also has been shown to inhibit glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression, or to induce reactive oxygen species-dependent apoptosis and G0/G1 cell cycle arrest through the MAPK/STAT3/NF-kappa pathway in human gastric cancer cells.
Purity:
>98% (HPLC)
SMILES:
OC1=C(OC)C=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=C1
Solubility Chemicals:
Sparingly soluble in water, DMSO or DMF (all <1mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) T.T. Song, et al.; J. Agric. Food Chem. 47, 1607 (1999) | (2) H. Yoshida, et al.; Biosci. Biotechnol. Biochem. 65, 1211 (2001) | (3) A. Gutierrez-Zepeda, et al.; BMC Neurosci. 6, 54 (2005) | (4) K.A. Kang, et al.; Free Radic. Res. 41, 720 (2007) | (5) E.J. Lee, et al.; Chem. Biol. Interact. 185, 18 (2010) | (6) M. Winzer, et al.; Wien. Med. Wochenschr. 160, 446 (2010) | (7) Y.Q. Zang, et al.; Drug Dev. Res. 80, 573 (2019)