Ginkgolide A
| Code | Size | Price |
|---|
| CDX-G0221-M025 | 25 mg | £121.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
BN-52020
Appearance:
White powder.
CAS:
15291-75-5
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1
InChiKey:
FPUXKXIZEIDQKW-VKMVSBOZSA-N
Long Description:
Chemical. CAS: 15291-75-5. Formula: C20H24O9. MW: 408.40. Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-kappa activity by NF-kappa-specific suppressor IkappaBalpha. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.
MDL:
MFCD00133365
Molecular Formula:
C20H24O9
Molecular Weight:
408.4
Package Type:
Vial
Product Description:
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-kappa activity by NF-kappa-specific suppressor IkappaBalpha. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.
Purity:
>98% (HPLC)
SMILES:
O=C1[C@@H](C)[C@]([C@](O1)([H])C2)(O)[C@]([C@]32[C@H]4C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O
Solubility Chemicals:
Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (3mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) H.W. Zhao & X.Y. Li; Int. Immunopharmacol. 2, 1551 (2002) | (2) H. Kuribara, et al.; J. Nat. Prod. 66, 1333 (2003) | (3) E. Koch; Phytomedicine 12, 10 (2005) | (4) B. Ye, et al.; Cancer Lett. 251, 43 (2007) | (5) Q. Zhao, et al.; Int. Immunopharmacol. 25, 242 (2015) | (6) N. Ye, et al.; Biomol. Ther. 24, 40 (2016) | (7) J. Zhaocheng, et al.; Pharmazie 71, 588 (2016) | (8) H.S. Jeong, et al.; Biomed. Pharmacother. 88, 625 (2017) | (9) Y. Li, et al.; Int. J. Mol. Sci. 18, E794 (2017) | (10) L.C. Kuo, et al.; J. Agric. Food Chem. 67, 81 (2019) | (11) S. Mohandas & B. Vairappan; Chem. Biol. Interact. 315, 108891 (2019) | (12) W. You, et al.; Pharmazie 74, 698 (2019)