Corilagin
Product Code:
CDX-C0650
CDX-C0650
Host Type:
Plant
Plant
Regulatory Status:
RUO
RUO
Shipping:
AMBIENT
AMBIENT
Storage:
+4°C
+4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CDX-C0650-M010 | 10 mg | £169.00 |
Quantity:
| CDX-C0650-M050 | 50 mg | £487.00 |
Quantity:
Prices exclude any Taxes / VAT
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* Rare exceptions are clearly labelled (only 0.14% of items!).
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
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Further Information
Alternate Names/Synonyms:
1-O-Galloyl-3,6-hexahydroxydiphenol-beta-D-Glucopyranose
Appearance:
White to off-white powder.
CAS:
23094-69-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19-,22-,23+,27+/m1/s1
InChiKey:
TUSDEZXZIZRFGC-XIGLUPEJSA-N
Long Description:
Chemical. CAS: 23094-69-1. Formula: C27H22O18. MW: 634.45. Isolated from plant source. Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants. It inhibits squalene epoxidase, a key enzyme in cholesterol synthesis and has various anti-inflammatory and anti-cancer effects. This compound displays the ability to inhibit NF-kappaB pathway activation and also prevent the release of TNF-alpha. Additional studies show that Corilagin significantly inhibits type 1 plasminogen activator inhibitor (PAI-1) in rat plasma. Shown to have antioxidant, antiviral and hepatoprotective properties. Induces apoptosis, autophagy and ROS generation in several cell lines.
MDL:
MFCD00238565
Molecular Formula:
C27H22O18
Molecular Weight:
634.45
Package Type:
Vial
Product Description:
Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants. It inhibits squalene epoxidase, a key enzyme in cholesterol synthesis and has various anti-inflammatory and anti-cancer effects. This compound displays the ability to inhibit NF-kappaB pathway activation and also prevent the release of TNF-alpha. Additional studies show that Corilagin significantly inhibits type 1 plasminogen activator inhibitor (PAI-1) in rat plasma. Shown to have antioxidant, antiviral and hepatoprotective properties. Induces apoptosis, autophagy and ROS generation in several cell lines.
Purity:
>98% (HPLC)
SMILES:
O=C(O[C@H]([C@H]1O)[C@H](O)[C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC3=O)C4=CC(O)=C(O)C(O)=C4C5=C3C=C(O)C(O)=C5O
Solubility Chemicals:
Soluble in DMSO, DMF or ethanol (all 20mg/ml). Slightly soluble in water (1mg/ml).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
Documents
References
(1) I. Abe, et al.; J. Nat. Prod. 64, 1010 (2001) | (2) S. Okabe, et al.; Biol. Pharm. Bull. 24, 1145 (2001) | (3) Z.Q. Shen, et al.; Planta Med. 69, 1109 (2003) | (4) S. Shiota, et al.; Microbiol. Immunol. 48, 67 (2004) | (5) S. Kinoshita, et al.; Phytomedicine 14, 755 (2007) | (6) X.R. Dong, et al.; Int. J. Mol. Med. 25, 531 (2010) | (7) R. Gambari, et al.; Intern. Immunopharmacol. 13, 308 (2012) | (8) H.T. Xiao, et al.; J. Nat. Prod. 76, 2120 (2013) | (9) L. Jia, et al.; BMC Complement. Altern. Med. 13, 33 (2013) | (10) R. Gambari, et al.; Phytother. Res. 28, 781 (2014) | (11) H.R. Li, et al.; BMC Complement. Altern. Med. 17, 18 (2017) | (12) B.U. Reddy, et al.; Antiviral Res. 150, 47 (2018) | (13) X. Li, et al.; Biomed. Pharmacother. 99, 43 (2018) (Review) | (14) J. Xu, et al.; Int. J. Mol. Med. 43, 967 (2019) | (15) H.S. Nandini & P.R. Naik; Chem. Biol. Interact. 299, 186 (2019)