3-Acetyl-11-keto-beta-boswellic acid
| Code | Size | Price |
|---|
| CDX-A0327-M005 | 5 mg | £157.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
AKBA; AKbetaBA; 3-O-Acetyl-11-keto-beta-boswellic acid
Appearance:
White to off-white powder.
CAS:
67416-61-9
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
InChiKey:
HMMGKOVEOFBCAU-BCDBGHSCSA-N
Long Description:
Chemical. CAS: 67416-61-9. Formula: C32H48O5. MW: 512.72. Isolated from plant source. 3-Acetyl-11-keto-beta-boswellic acid (AKBA) antitumor and anti-inflammatory activities. It is a potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. It exhibits in vivo efficacy in tumor growth inhibition and has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
MDL:
MFCD03788777
Molecular Formula:
C32H48O5
Molecular Weight:
512.72
Package Type:
Vial
Product Description:
3-Acetyl-11-keto-beta-boswellic acid (AKBA) antitumor and anti-inflammatory activities. It is a potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. It exhibits in vivo efficacy in tumor growth inhibition and has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
Purity:
>98% (HPLC)
SMILES:
O=C1[C@@]([C@](CC2)(C)[C@@]([C@@](C)(C(O)=O)[C@@H]2OC(C)=O)([H])CC3)([H])[C@]3(C)[C@@]4(C)C([C@@]([C@@H](C)[C@H](C)CC5)([H])[C@@]5(C)CC4)=C1
Solubility Chemicals:
Soluble in chloroform, methanol, DMSO (25mg/ml), DMF (25mg/ml) or ethanol (5mg/ml).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) H. Safayhi, et al.; J. Pharmacol. Exp. Ther. 261, 1143 (1992) | (2) R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther. 288, 613 (1999) | (3) A. Altmann, et al.; BBRC 290, 185 (2002) | (4) A. Altmann, et al.; Br. J. Pharmacol. 141, 223 (2004) | (5) T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) | (6) L. Xia, et al.; Mol. Cancer Therap. 4, 381 (2005) | (7) M. Bishnoi, et al.; Indian J. Exp. Biol. 44, 128 (2006) | (8) C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006) | (9) D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006) (Review)