(-)-Epicatechin
| Code | Size | Price |
|---|
| CDX-E0231-M005 | 5 mg | £101.00 |
Quantity:
| CDX-E0231-M025 | 25 mg | £328.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
EC; epi-Catechin; NSC81161; (-)-cis-3,3',4',5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
Appearance:
White to off-white powder.
CAS:
490-46-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
InChiKey:
PFTAWBLQPZVEMU-UKRRQHHQSA-N
Long Description:
Chemical. CAS: 490-46-0. Formula: C15H14O6. MW: 290.27. Isolated from plant source. Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect in diabetes and cancer conditions. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while its anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. The activity of Epicatechin includes the ability to interact with and neutralize reactive oxygen species (ROS), and to modulate cell signaling including the MAP kinase pathway, which is involved in cell proliferation.
MDL:
MFCD00075648
Molecular Formula:
C15H14O6
Molecular Weight:
290.27
Package Type:
Vial
Precautions:
P261-P305 + P351 + P338
Product Description:
Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect in diabetes and cancer conditions. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while its anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. The activity of Epicatechin includes the ability to interact with and neutralize reactive oxygen species (ROS), and to modulate cell signaling including the MAP kinase pathway, which is involved in cell proliferation.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
OC1=CC(O)=C(C[C@@H](O)[C@@H](C2=CC=C(O)C(O)=C2)O3)C3=C1
Solubility Chemicals:
Soluble in acetone:water (1:1, 10 mg/ml), DMSO (10 mg/ml), methanol or DMF (~12.5 mg/ml).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) F. Bonilla, et al.; Food Chem. 66, 209 (1999) | (2) M. Suganuma, et al.; Cancer Res. 59, 44 (1999) | (3) J. Terao; J. Med. Invest. 46, 159 (1999) (Review) | (4) J.Z. Xu, et al.; Br. J. Nutr. 91, 873 (2004) | (5) M.H. Ravindranath, et al.; Evidence-Based Compl. Altern. Med. 6, 523 (2009) | (6) C.G. Fraga & P.I. Oteiza; Free Radic. Biol. Med. 51, 813 (2011) (Review) | (7) J. Shay, et al.; Oxid. Med. Cell Longev. 2015, 181260 (2015) (Review) | (8) L.A. Abdulkhaleq, et al.; Vet. World 10, 869 (2017) (Review)