Psoralen
| Code | Size | Price |
|---|
| CDX-P0593-M010 | 10 mg | £72.00 |
Quantity:
| CDX-P0593-M025 | 25 mg | £121.00 |
Quantity:
| CDX-P0593-M100 | 100 mg | £340.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
Ficusin; Furocoumarin; 6,7-Furanocoumarin; NSC 404562; 7H-Furo[3,2-g]benzopyran-7-one; Furo[3,2-g]coumarin
Appearance:
White to off-white powder.
CAS:
66-97-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H315-H319-H335
InChi:
InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
InChiKey:
ZCCUUQDIBDJBTK-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 66-97-7. Formula: C11H6O3. MW: 186.16. Isolated from plant source. Psoralen is a photoactive probe that has been used to investigate nucleic acid structure and function. It intercalates into DNA and, when activated by ultraviolet radiation, can create covalent interstrand crosslinks, inducing apoptosis. Photosensitizing agent that shows anticancer properties by inducing apoptosis and cell cycle arrest, modulating the Wnt/beta-catenin pathway. This compound is also used in molecular biology applications. Because of its high UV absorbance, psoralen has been combined with UVA light (PUVA therapy) for the treatment of skin problems such as psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma. Spectral fluorescence: lambdaex=335nm; lambdaem=460nm (pH 7.0).
MDL:
MFCD00010520
Molecular Formula:
C11H6O3
Molecular Weight:
186.16
Package Type:
Vial
Precautions:
P261-P305 + P351 + P338
Product Description:
Psoralen is a photoactive probe that has been used to investigate nucleic acid structure and function. It intercalates into DNA and, when activated by ultraviolet radiation, can create covalent interstrand crosslinks, inducing apoptosis. Photosensitizing agent that shows anticancer properties by inducing apoptosis and cell cycle arrest, modulating the Wnt/beta-catenin pathway. This compound is also used in molecular biology applications. Because of its high UV absorbance, psoralen has been combined with UVA light (PUVA therapy) for the treatment of skin problems such as psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma. Spectral fluorescence: lambdaex=335nm; lambdaem=460nm (pH 7.0).
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
O=C1C=CC2=C(C=C(OC=C3)C3=C2)O1
Solubility Chemicals:
Soluble in DMSO (20mg/ml), DMF (20mg/ml), ethanol (5 mg/ml), ethyl acetate, acetone or water (1mg/ml with warming).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) K.M. Vasquez; Environ. Mol. Mutagen 51, 527 (2010) | (2) A. Litovchick, et al.; Artif.DNA PNA XNA 5, (2014) | (3) X. Wang, et al.; Biol. Pharm. Bull. 39, 815 (2016) | (4) M. Oldham, et al.; PLoS One 11, e0162078 (2016) | (5) F. Kouzine, et al.; Methods Mol. Biol. 1703, 95 (2018) | (6) X. Wang, et al.; Sci. Rep. 8, 14001 (2018) | (7) J. Guitart; JAMA Dermatol. 155, 529 (2019) |(8) X. Wang, et al.; Biol. Res. 52, 34 (2019)