Oxymatrine
| Code | Size | Price |
|---|
| CDX-O0077-M100 | 100 mg | £84.00 |
Quantity:
| CDX-O0077-M500 | 500 mg | £164.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
Matrine 1-oxide; Matrine N-oxide; Ammothamnine
Appearance:
White to off-white powder.
CAS:
16837-52-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302
InChi:
InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
InChiKey:
XVPBINOPNYFXID-LHDUFFHYSA-N
Long Description:
Chemical. CAS: 16837-52-8. Formula: C15H24N2O2. MW: 264.36. Isolated from plant source. Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-beta signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-kappaB. Neuroprotective by inhibition of apoptosis in neurons.
MDL:
MFCD00210339
Molecular Formula:
C15H24N2O2
Molecular Weight:
264.36
Package Type:
Vial
Precautions:
P264+P270+P301+P312+P330+P501
Product Description:
Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-beta signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-kappaB. Neuroprotective by inhibition of apoptosis in neurons.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
[O-][N+]12CCC[C@]3([H])[C@@]1([H])[C@]([C@](CCCC4=O)([H])N4C3)([H])CCC2
Solubility Chemicals:
Soluble in ethanol (25mg/ml), methanol, DMSO, DMF or water (all 10mg/ml).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) X.L. Wu, et al.; World J. Gastroenterol. 14, 2100 (2008) | (2) J.W. Ngan, et al.; Anticancer Agents Med. Chem. 9, 823 (2009) (Review) | (3) X. Cui, et al.; Biosci. Trends 4, 39 (2010) | (4) X.Q. Dong, et al.; Inflamm. Res. 60, 533 (2010) | (5) Q. Ling, et al.; J. Exp. Clin. Cancer Res. 30, 66 (2011) | (6) X.C. Shen, et al.; J. Asian Nat. Prod. Res. 13, 215 (2011) | (7) N.L. Chai, et al.; World J. Gastroenterol. 18, 4199 (2012) | (8) J.R. Guzman, et al.; Sci. Rep. 3, 1629 (2013) | (9) C.E. Halim, et al.; Pharmacol. Res. 147, 104327 (2019) (Review)