Tanshinone I
| Code | Size | Price |
|---|
| CDX-T0417-M005 | 5 mg | £59.00 |
Quantity:
| CDX-T0417-M025 | 25 mg | £205.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
Tanshinon I; Tanshinone A; 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione
Appearance:
Purple-black powder.
CAS:
568-73-0
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
Hazards:
H413
InChi:
InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChiKey:
AIGAZQPHXLWMOJ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 568-73-0. Formula: C18H12O3. MW: 276.29. Isolated from plant source. Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, anti-inflammatory, immunosuppressive, anticoagulant and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity. It has been shown to induce apoptosis in several cancer cell lines. It reduces plasma levels of total cholesterol, triglycerides, LDL and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in microglia in vitro. It is neuroprotective in a mouse model of Parkinson's disease induced by MPTP.
MDL:
MFCD00210563
Molecular Formula:
C18H12O3
Molecular Weight:
276.29
Package Type:
Vial
Precautions:
P273+P501
Product Description:
Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, anti-inflammatory, immunosuppressive, anticoagulant and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity. It has been shown to induce apoptosis in several cancer cell lines. It reduces plasma levels of total cholesterol, triglycerides, LDL and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in microglia in vitro. It is neuroprotective in a mouse model of Parkinson's disease induced by MPTP.
Purity:
>98% (HPLC)
SMILES:
O=C(C1=C(C2=C3C(C)=CO2)C=CC4=C1C=CC=C4C)C3=O
Solubility Chemicals:
Soluble in DMSO, chloroform or methanol.
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) J.Y. Kim, et al.; Pharmacol. Toxicol. 92, 195 (2003) | (2) I.T. Nizamutdinova, et al.; Carcinogenesis 29, 1885 (2008) | (3) I.T. Nizamutdinova, et al.; Int. J. Oncol. 33, 485 (2008) | (4) C.Y. Lee, et al.; Mol. Cancer Ther. 7, 3527 (2008) | (5) L. Yang, et al.; PLoS One 8, e80464 (2013) | (6) J.H. Park, et al.; Neurochem. Res. 39, 1300 (2014) | (7) S. Wang, et al.; J. Ethnaopharmacol. 164, 247 (2015) | (8) M.K. Kim, et al.; Fitoterapia 101, 162 (2015) | (9) X. Jing, et al.; Neurochem. Res. 41, 779 (2016) | (10) Y. Wei, et al.; Biomed. Pharmacother. 93, 352 (2017) | (11) Q.-T. Tian, et al.; Biochem. Pharmacol. 156, 255 (2018) | (12) Y. Yan, et al.; Mol. Pharm. 15, 4843 (2018)