Genistin
| Code | Size | Price |
|---|
| CDX-G0191-M005 | 5 mg | £59.00 |
Quantity:
| CDX-G0191-M025 | 25 mg | £194.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Plant
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Genistein glycoside; NSC 5112; 4',5,7-Trihydroxyisoflavone 7-glucoside
Appearance:
Light-Yellow Powder.
CAS:
529-59-9
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
InChiKey:
ZCOLJUOHXJRHDI-CMWLGVBASA-N
Long Description:
Chemical. CAS: 529-59-9. Formula: C21H20O10. MW: 432.38. Isolated from plant source. Genistin is a natural isoflavone glycoside isolated from legumes (e.g. soy). It is a selective inhibitor of mammalian terminal deoxyribonucleotidyl-transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases. Disrupts cell cycle and induces apoptosis in human ovarian cancer SK-OV-3 cells. Inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo. Could also be used as a negative control for the PTK inhibitor Genistein.
MDL:
MFCD00016883
Molecular Formula:
C21H20O10
Molecular Weight:
432.38
Package Type:
Vial
Product Description:
Genistin is a natural isoflavone glycoside isolated from legumes (e.g. soy). It is a selective inhibitor of mammalian terminal deoxyribonucleotidyl-transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases. Disrupts cell cycle and induces apoptosis in human ovarian cancer SK-OV-3 cells. Inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo. Could also be used as a negative control for the PTK inhibitor Genistein.
Purity:
>97% (HPLC)
SMILES:
OC[C@H]1O[C@@H](OC2=CC(OC=C(C3=CC=C(O)C=C3)C4=O)=C4C(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O
Solubility Chemicals:
Soluble in DMSO (10mg/ml) or DMF (10mg/ml).
Source / Host:
Isolated from plant source.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) C.D. Allred, et al.; Carcinogenesis 22, 1667 (2001) | (2) T. Uesugi, et al.; Biol. Pharm. Bull. 24, 368 (2001) | (3) Y. Uchiyama, et al.; Biochim. Biophys. Acta, 1725, 298 (2005) | (4) A. Russo, et al.; J. Nutr. Biochem. 17, 103 (2006) | (5) E.J. Choi, et al.; Life Sci. 80, 1403 (2007) | (6) R.W. Wong & A.B. Rabie; Front. Biosci. 2, 764 (2010)