Micafungin sodium

Mycamine; Funguard; FK463; 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 sodium salt

White to beige powder.

208538-73-2

32160000

liquid

Protect from light and moisture.

InChI=1S/C56H71N9O23S.Na/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76;/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85);/q;+1/p-1/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+;/m0./s1

KOOAFHGJVIVFMZ-WZPXRXMFSA-M

Chemical. CAS: 208538-73-2. Formula: C56H70N9NaO23S. MW: 1292.26. Semisynthetic. Micafungin is a semisynthetic echinocandin antifungal. Micafungin inhibits the enzyme beta(1,3)-D-Glucan synthase, consequently 1,3-beta-D-glucan synthesis and thereby disturbing the integrity of the fungal cell wall. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp. The target enzyme does not exist in mammalian systems.

MFCD08067752

C56H70N9NaO23S

1292.26

Vial

Micafungin is a semisynthetic echinocandin antifungal. Micafungin inhibits the enzyme beta(1,3)-D-Glucan synthase, consequently 1,3-beta-D-glucan synthesis and thereby disturbing the integrity of the fungal cell wall. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp. The target enzyme does not exist in mammalian systems.

>97% (HPLC)

O[C@@H]([C@@H](C)C1)[C@@H](C(N[C@@H]([C@@H](C2)O)O)=O)N1C([C@H]([C@@H](CC(N)=O)O)NC([C@H]([C@@H]([C@H](C(C=C3)=CC(OS([O-])(=O)=O)=C3O)O)O)NC([C@H](C[C@H]4O)N(C4)C([C@H]([C@@H](C)O)NC([C@H]2NC(C(C=C5)=CC=C5C6=NOC(C(C=C7)=CC=C7OCCCCC)=C6)=O)=O)=O)=O)=O)=O.[Na+]

Soluble in DMSO or DMF (both 10mg/ml). Slightly soluble in ethanol, methanol or water (all 1mg/ml).

Semisynthetic

Non-hazardous

Biochemical Reagents

12352200

Stable for at least 2 years after receipt when stored at -20°C.