Moxidectin

23-Methoxime-LL-F 28249alpha; CL 301423

Yellow powder.

113507-06-5

6.1

32160000

solid

GHS06,GHS09

Protect from light and moisture.

H301-H400

InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

YZBLFMPOMVTDJY-LSGXYNIPSA-N

Chemical. CAS: 113507-06-5. Formula: C37H53NO8. MW: 639.82. Moxidectin is broad-spectrum antiparasitic agent used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells. When moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Moxidectin selectively enhanced the tonic GABA conductance of hippocampal pyramidal neurons in rats. Moxidectin is also used in the treatment of onchocerciasis, against acaricides/miticides, as well as in the prevention and treatment of other parasitic infections in veterinary medicine. Moxidectin belongs to the milbemycin familyand is similar to avermectins in terms of chemical strucutre. It might have some antitumor and multidrug resistance properties.

MFCD00866560

C37H53NO8

639.82

Vial

II

Moxidectin is broad-spectrum antiparasitic agent used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells. When moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Moxidectin selectively enhanced the tonic GABA conductance of hippocampal pyramidal neurons in rats. Moxidectin is also used in the treatment of onchocerciasis, against acaricides/miticides, as well as in the prevention and treatment of other parasitic infections in veterinary medicine. Moxidectin belongs to the milbemycin familyand is similar to avermectins in terms of chemical strucutre. It might have some antitumor and multidrug resistance properties.

EP

Danger

O[C@]1([C@](C=C2C)([H])C(O[C@](C3)([H])C4)=O)[C@]([C@@H]2O)([H])OC/C1=CC=C[C@H](C)C/C(C)=C/C[C@@]3([H])O[C@]4(C/5)O[C@H](/C(C)=C/C(C)C)[C@@H](C)C5=NOC

Soluble in DMSO, ethanol or DMF (all 20mg/ml).

Semisynthetic

Excepted Quantity

2811

Biochemical Reagents

12352200

Stable for at least 2 years after receipt when stored at -20°C.