Telmisartan
| Code | Size | Price |
|---|
| CDX-T0460-M010 | 10 mg | £41.00 |
Quantity:
| CDX-T0460-M050 | 50 mg | £102.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
BIBR 277; Micardis; Pritor; 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
Appearance:
White to off-white solid.
CAS:
144701-48-4
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChiKey:
RMMXLENWKUUMAY-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 144701-48-4. Formula: C33H30N4O2. MW: 514.62. Synthetic. Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively inhibits the angiotensin II AT1 receptor subtype (Ki=3.7nM). Telmisartan exhibits antihypertensive activity in a renin-dependent model of hypertension. In addition to blocking the renin-angiotensin system (RAS), telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-gamma), a central regulator of insulin and glucose metabolism and improving insulin sensitivity. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk and glomerulosclerosis. Furthermore, telmisartan inhibits proliferation in several cancer models by inducing apoptosis and cell cycle arrest.
MDL:
MFCD00918125
Molecular Formula:
C33H30N4O2
Molecular Weight:
514.62
Package Type:
Vial
Product Description:
Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively inhibits the angiotensin II AT1 receptor subtype (Ki=3.7nM). Telmisartan exhibits antihypertensive activity in a renin-dependent model of hypertension. In addition to blocking the renin-angiotensin system (RAS), telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-gamma), a central regulator of insulin and glucose metabolism and improving insulin sensitivity. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk and glomerulosclerosis. Furthermore, telmisartan inhibits proliferation in several cancer models by inducing apoptosis and cell cycle arrest.
Purity:
>98% (HPLC)
SMILES:
CN1C2=CC=CC=C2N=C1C3=CC(N(CC4=CC=C(C5=CC=CC=C5C(O)=O)C=C4)C(CCC)=N6)=C6C(C)=C3
Solubility Chemicals:
Soluble in DMSO, chloroform, DMF or ethanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) U.J. Ries, et al.; J. Med. Chem. 36, 4040 (1993) | (2) W. Wienen, et al.; Br. J. Pharmacol. 110, 245 (1993) | (3) K.J. McClellan & A. Markham; Drugs 56, 1039 (1998) | (4) S.C. Benson, et al.; Hypertension 43, 993 (2004) | (5) X. Rong, et al.; J. Pharmacol. Exp. Ther. 331, 1096 (2009) | (6) R.E. Schmieder, et al.; J. Nephrol. 24, 263 (2011) | (7) J.E. Frampton; Drugs 71, 651 (2011) (Review) | (8) T. Kozako, et al.; FEBS Open Bio 6, 442 (2016) | (9) E. Samukawa, et al.; Int. J. Oncol. 51, 1674 (2017)