Fluticasone propionate
| Code | Size | Price |
|---|
| CDX-F0325-M005 | 5 mg | £65.00 |
Quantity:
| CDX-F0325-M025 | 25 mg | £175.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
Fluticasone 17-Propionate; (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester; CCI 18781
Appearance:
White powder.
CAS:
80474-14-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
InChiKey:
WMWTYOKRWGGJOA-CENSZEJFSA-N
Long Description:
Chemical. CAS: 80474-14-2. Formula: C25H31F3O5S. MW: 500.57. Fluticasone propionate is a synthetic corticosteroid. It is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5nM). It is used as an anti-inflammatory agent for asthma. It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis and other airway diseases. It potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis in vitro. It also potentiates KV1 channels (EC50 = 37nM).
MDL:
MFCD00866007
Molecular Formula:
C25H31F3O5S
Molecular Weight:
500.57
Package Type:
Vial
Product Description:
Fluticasone propionate is a synthetic corticosteroid. It is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5nM). It is used as an anti-inflammatory agent for asthma. It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis and other airway diseases. It potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis in vitro. It also potentiates KV1 channels (EC50 = 37nM).
Purity:
>97% (NMR)
SMILES:
O[C@H]1C[C@@]2(C)[C@](C[C@@H](C)[C@]2(OC(CC)=O)C(SCF)=O)([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@]31F)=O
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or DMF (20mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) M. Johnson; Allergy 50, 11 (1995) (Review) | (2) M. Johnson; Int. Arch. Allergy Immunol. 107, 439 (1995) (Review) | (3) R. Fuller, et al.; Respir. Med. 89, 3 (1995) (Review) | (4) C.L. Smith & W. Kreutner; Arzneim.-Forsch. 48, 956 (1998) | (5) X. Zhang, et al.; Eur. J. Pharmacol. 406, 325 (2000) | (6) Y. Pan, et al.; ACS Chem Biol. 7, 1641 (2012) | (7) J. Sastre & R. Mosges; J. Investig. Allergol. Clin. Immunol. 22, 1 (2012) | (8) J. Gonzalez-Cervera & A.J. Lucendo; J. Investig. Allergol. Clin. Immunol. 26, 8 (2016)