BAPTA (free acid)
| Code | Size | Price |
|---|
| CDX-B0217-M250 | 250 mg | £41.00 |
Quantity:
| CDX-B0217-G001 | 1 g | £102.00 |
Quantity:
| CDX-B0217-G005 | 5 g | £377.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
Appearance:
White to off-white powder.
CAS:
85233-19-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)
InChiKey:
FTEDXVNDVHYDQW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 85233-19-8. Formula: C22H24N2O10. MW: 476.4. BAPTA is a membrane-impermeable highly selective calcium chelator and is useful for manipulating extracellular Ca2+ levels, with 105-fold greater affinity for Ca2+ than for Mg2+. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives can be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). Key advantages of BAPTA include relative insensitivity toward intracellular pH change and fast release of calcium. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction, apoptotic cascades and neuroscience research.
MDL:
MFCD00036255
Molecular Formula:
C22H24N2O10
Molecular Weight:
476.4
Package Type:
Vial
Product Description:
BAPTA is a membrane-impermeable highly selective calcium chelator and is useful for manipulating extracellular Ca2+ levels, with 105-fold greater affinity for Ca2+ than for Mg2+. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives can be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). Key advantages of BAPTA include relative insensitivity toward intracellular pH change and fast release of calcium. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction, apoptotic cascades and neuroscience research.
Purity:
>98%
SMILES:
O=C(O)CN(CC(O)=O)C1=C(OCCOC2=C(N(CC(O)=O)CC(O)=O)C=CC=C2)C=CC=C1
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or DMF (20mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) R.Y. Tsien, et al.; Biochemistry. 19, 2396 (1980) | (2) R.Y. Tsien, et al.; Annu. Rev. Biophys. Bioeng. 12, 91 (1983) | (3) G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) | (4) H. Kijima, et al.; J. Physiol. 403, 135 (1988) | (5) N. Tanabe, et al.; Neurosci. Lett. 92, 52 (1988) | (6) R.C. Hardie; Cell Calcium. 38, 547 (2005) | (7) R.W. Sabnis; Handbook of biological dyes and stains (2010)