Umbelliferon

7-Hydroxycoumarin; 7-Hydroxy-2H-1-benzopyran-2-one; NSC 19790

Beige solid.

93-35-6

32160000

liquid

Protect from light and moisture.

InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H

ORHBXUUXSCNDEV-UHFFFAOYSA-N

Chemical. CAS: 93-35-6. Formula: C9H6O3. MW: 162.14. Synthetic. Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, antihyperglycemic, anti-inflammatory, neuroprotective and antidepressant-like properties. It inhibits the growth of a variety of human cell lines. It increases the production of reactive oxygen species (ROS), depolarizes the mitochondrial membrane, and halts the cell cycle at the G0/G1 phase in KB human oral carcinoma cells. Umbelliferone has been used as a ratiometric pH indicator. Spectral Data: Em=460nm / Ex=330(ph<6)/370nm(pH>8). Umbelliferone can also be used as building block to synthesize fluorescent probes or biochemically active APIs.

MFCD00006878

C9H6O3

162.14

Vial

Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, antihyperglycemic, anti-inflammatory, neuroprotective and antidepressant-like properties. It inhibits the growth of a variety of human cell lines. It increases the production of reactive oxygen species (ROS), depolarizes the mitochondrial membrane, and halts the cell cycle at the G0/G1 phase in KB human oral carcinoma cells. Umbelliferone has been used as a ratiometric pH indicator. Spectral Data: Em=460nm / Ex=330(ph<6)/370nm(pH>8). Umbelliferone can also be used as building block to synthesize fluorescent probes or biochemically active APIs.

>98% (NMR)

O=C1OC2=CC(O)=CC=C2C=C1

Soluble in DMSO (10mg/ml), ethanol (5 mg/ml), methanol (5 mg/ml) or dioxane.

Synthetic

Non-hazardous

Natural Products/Extracts

12352200

Stable for at least 2 years after receipt when stored at +4°C.