IR-783
| Code | Size | Price |
|---|
| CDX-I0058-M250 | 250 mg | £84.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
2-[2-[2-Chloro-3-[2-[1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene]-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-3,3-dimethyl-1-(4-sulfobutyl)-3H-indolium hydroxide, inner salt sodium salt
Appearance:
Dark red to brown powder.
CAS:
115970-66-6
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C38H47ClN2O6S2.Na/c1-37(2)30-16-5-7-18-32(30)40(24-9-11-26-48(42,43)44)34(37)22-20-28-14-13-15-29(36(28)39)21-23-35-38(3,4)31-17-6-8-19-33(31)41(35)25-10-12-27-49(45,46)47;/h5-8,16-23H,9-15,24-27H2,1-4H3,(H-,42,43,44,45,46,47);/q;+1/p-1
InChiKey:
QQIQAVJARACLHE-UHFFFAOYSA-M
Long Description:
Chemical. CAS: 115970-66-6. Formula: C38H46ClN2NaO6S2. MW: 749.37. Synthetic. IR-783 is a functional laser and near-IR (NIR) dye. Spectral data: Absorption lambdamax=783nm (MeOH). IR-783 has been shown to be a dye that exhibits imaging, cancer targeting and anticancer properties. Useful optical probe for NIR imaging of tumors, shown to accumulate in the mitochondria and lysosomes of cancer cells. IR-783 inhibits cell viability and induces mitochondrial apoptosis in human breast cancer cells and induces cell proliferation in a dose- and time-dependent manner by inducing cell cycle arrest at the G0/G1 phase.
MDL:
MFCD03427057
Molecular Formula:
C38H46ClN2NaO6S2
Molecular Weight:
749.37
Package Type:
Vial
Product Description:
IR-783 is a functional laser and near-IR (NIR) dye. Spectral data: Absorption lambdamax=783nm (MeOH). IR-783 has been shown to be a dye that exhibits imaging, cancer targeting and anticancer properties. Useful optical probe for NIR imaging of tumors, shown to accumulate in the mitochondria and lysosomes of cancer cells. IR-783 inhibits cell viability and induces mitochondrial apoptosis in human breast cancer cells and induces cell proliferation in a dose- and time-dependent manner by inducing cell cycle arrest at the G0/G1 phase.
Purity:
>98% (HPLC)
SMILES:
ClC1=C(/C=C/C2=[N+](CCCCS(=O)(O[Na])=O)C3=C(C=CC=C3)C2(C)C)CCC/C1=CC=C4N(CCCCS(=O)([O-])=O)C(C=CC=C5)=C5C/4(C)C
Solubility Chemicals:
Soluble in water or methanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) K. Leung; Mol. Imag. Contrast Agent Datab. (2010) | (2) X. Yang, et al.; Clin. Cancer Res. 16, 2833 (2010) | (3) K. Leung; Mol. Imag. Contrast Agent Datab. (2011) | (4) X. Yang, et al.; J. Urol. 189, 702 (2013) | (1) C. Shao, et al.; PLoS One 9, e88967 (2014) | (6) I. Semenenko, et al.; Front. Pharmacol. 7, 426 (2016) | (7) Q. Tang, et al.; J. Cell Mol. Med. 22, 4474 (2018) | (8) P. Li, et al.; Int. J. Oncol. 55, 415 (2019)