Medetomidine HCl
| Code | Size | Price |
|---|
| CDX-M0559-M010 | 10 mg | £96.00 |
Quantity:
| CDX-M0559-M050 | 50 mg | £353.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride; Domitor; MPV 785; Metomidine; Zalopine; Detomidine HCl
Appearance:
White to off-white powder.
CAS:
86347-15-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
InChiKey:
VPNGEIHDPSLNMU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 86347-15-1. Formula: C13H17ClN2. MW: 236.75. Synthetic. Medetomidine is an imidazole derivative. It acts as a potent selective agonist of alpha2-adrenoceptors (Ki=1.08nM vs. 1750nM for alpha1-adrenoceptors). Through its effect on alpha2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by alpha2-adrenoceptor antagonists, like atipamezole. Selective alpha2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the alpha2-adrenoceptor agonist.
MDL:
MFCD06798319
Molecular Formula:
C13H17ClN2
Molecular Weight:
236.75
Package Type:
Vial
Precautions:
P261-P305+P351+P338-P302+P352
Product Description:
Medetomidine is an imidazole derivative. It acts as a potent selective agonist of alpha2-adrenoceptors (Ki=1.08nM vs. 1750nM for alpha1-adrenoceptors). Through its effect on alpha2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by alpha2-adrenoceptor antagonists, like atipamezole. Selective alpha2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the alpha2-adrenoceptor agonist.
Purity:
>98%
Signal word:
Warning
SMILES:
CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl
Solubility Chemicals:
Soluble in water (20mg/ml) or DMSO (20mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) J.M. Savola, et al.; J. Auton. Pharmacol. 6, 275 (1986) | (2) R. Virtanen, et al.; Eur. J. Pharmacol. 150, 9 (1988) | (3) M.H. Ossipov, et al.; Anesthesiology 73, 1227 (1990) | (4) T.F. Meert, & M. de Kock; Anesthesiology 81, 677 (1994) | (5) J.C. Hunter, et al.; Br. J. Pharmacol. 122, 1339 (1997) | (6) H. Scheinin, et al.; Anesthesiology 89, 574 (1998) | (7) M.D. Sinclair; Can. Vet. J. 44, 885 (2003)