beta-Nicotinamide adenine dinucleotide phosphate
| Code | Size | Price |
|---|
| CDX-N0151-M500 | 500 mg | £145.00 |
Quantity:
| CDX-N0151-G001 | 1 g | £224.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Coenzyme II; beta-NADP; NADP+; TPN; Triphosphopyridine nucleotide sodium salt hydrate
Appearance:
White to off-white powder.
CAS:
698999-85-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H319
InChi:
InChI=1S/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1
InChiKey:
JNUMDLCHLVUHFS-QYZPTAICSA-M
Long Description:
Chemical. CAS: 698999-85-8. Formula: C21H27N7NaO17P3 . xH2O. MW: 765.39 (anhydrous basis). NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. It is a cofactor used in anabolic reactions, such as the Calvin cycle, lipid syntheses and nucleic acid syntheses, which require NADPH as a reducing agent. It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status and intracellular signaling. For example, binding of NADP+ to beta-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor. NADP+ might be useful for immunometabolism research.
MDL:
MFCD00150480
Molecular Formula:
C21H27N7NaO17P3 . xH2O
Molecular Weight:
765.39 (anhydrous basis)
Package Type:
Vial
Precautions:
P280-P305 + P351 + P338-P337 + P313
Product Description:
NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. It is a cofactor used in anabolic reactions, such as the Calvin cycle, lipid syntheses and nucleic acid syntheses, which require NADPH as a reducing agent. It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status and intracellular signaling. For example, binding of NADP+ to beta-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor. NADP+ might be useful for immunometabolism research.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP([O-])(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O.[Na+]
Solubility Chemicals:
Soluble in water (30mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) F. Shi, et al.; Acta Biochim. Biophys. Sin. 41, 352 (2009) | (2) J.B. Jackson; BBA 1817, 1839 (2012) | (3) M. Nakamura, et al.; Circ. Res. 111, 604 (2012) | (4) P.J. Kilfoil, et al.; Circ. Res. 112, 721 (2013) | (5) M. Ziegler; FEBS J. 272, 4561 (2014) | (6) R. Ramalho, et al.; Sem. Immunopathol. 42, 279 (2020)