Caspofungin diacetate
| Code | Size | Price |
|---|
| CDX-C0267-M005 | 5 mg | £72.00 |
Quantity:
| CDX-C0267-M025 | 25 mg | £255.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
L-743,872; MK 0991
Appearance:
White to beige powder.
CAS:
179463-17-3
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-;;/m0./s1
InChiKey:
OGUJBRYAAJYXQP-IJFZAWIJSA-N
Long Description:
Chemical. CAS: 179463-17-3. Formula: C52H88N10O15 ? 2C2H4O2. MW: 1213.42. Caspofungin acetate is an antifungal compound that is classified as an echinocandin. It is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by non-competititvely inhibiting the enzyme 1,3-beta glucan synthase and preventing the synthesis of glucan and distutbing the integrity in the fungal cell wall. This agent is used in fungal cell wall biosynthesis research to study the role of beta-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. It is effective against disseminated or invasive aspergillosis and candidiasis in mice.
MDL:
MFCD08141839
Molecular Formula:
C52H88N10O15 . 2C2H4O2
Molecular Weight:
1213.42
Package Type:
Vial
Product Description:
Caspofungin acetate is an antifungal compound that is classified as an echinocandin. It is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by non-competititvely inhibiting the enzyme 1,3-beta glucan synthase and preventing the synthesis of glucan and distutbing the integrity in the fungal cell wall. This agent is used in fungal cell wall biosynthesis research to study the role of beta-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. It is effective against disseminated or invasive aspergillosis and candidiasis in mice.
Purity:
>98% (HPLC)
SMILES:
OC(C)=O.O=C([C@H]([C@@H](CCN)O)NC([C@H]([C@@H]([C@H](C(C=C1)=CC=C1O)O)O)NC([C@H](C2)N(C[C@@H]2O)C([C@H]([C@@H](C)O)NC([C@@H](NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)C3)=O)=O)=O)=O)N4[C@@](C(N[C@@H]([C@@H]3O)NCCN)=O)([H])[C@@H](O)CC4.O=C(C)O
Solubility Chemicals:
Soluble in DMSO (25mg/ml), DMF (20mg/ml), ehtanol (20mg/ml) or water (15mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) G.K. Abruzzo, et al.; Antimicrob. Agents Chemother. 41, 2333 (1997) | (2) V. Letscher-Bru, et al.; J. Antimicrob. Chemother. 51, 513 (2003) | (3) S.C. Deresinski & D.A. Stevens; Clin. Infect. Dis. 36, 1445 (2003) | (4) R. Herbrecht, et al.; J. Antimicrob. Chemother. 56, i39 (2005) | (5) M.A. Pfaller, et al.; J. Clin. Microbiol. 47, 3323 (2009) | (6) J.M. Balkovec, et al.; Nat. Prod. Rep. 31, 15 (2014)