Ascorbic acid 6-palmitate
| Code | Size | Price |
|---|
| CDX-A0534-G025 | 25 g | £53.00 |
Quantity:
| CDX-A0534-G100 | 100 g | £108.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
AA6P; 6-O-Palmitoyl-L-ascorbic acid; Ascorbylpalmitic Acid; L-Ascorbic acid 6-hexadecanoate; L-Ascorbyl palmitate; Ascorbic acid 6-palmitate; NSC 402451
Appearance:
Light yellow powder.
CAS:
137-66-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21-/m0/s1
InChiKey:
QAQJMLQRFWZOBN-UWJYYQICSA-N
Long Description:
Chemical. CAS: 137-66-6. Formula: C22H38O7. MW: 414.53. Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin's lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases.
MDL:
MFCD00005377
Molecular Formula:
C22H38O7
Molecular Weight:
414.53
Package Type:
Vial
Product Description:
Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin's lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases.
Purity:
>95%
SMILES:
OC1=C(O)C(O[C@@]1([H])[C@H](COC(CCCCCCCCCCCCCCC)=O)O)=O
Solubility Chemicals:
Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (10mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) W.M. Cort; J. Am. Oil Chem. Soc. 51, 321 (1974) | (2) R.C. Smart & C.L. Crawford; Am. J. Clin. Nutr. 54, 1266S (1991) | (3) H. Chen & A.L. Tappel; Free Radic. Res. 22, 177 (1995) | (4) N. Perricone, et al.; BBRC 262, 661 (1999) | (5) O. Yilmaz, et al.; J. Cell Biochem. 86, 530 (2002) | (6) A. Meves, et al.; J. Invest. Dermatol. 119, 1103 (2002) | (7) K.M. Lee, et al.; Mutat. Res. 660, 51 (2009) | (8) S.K. Karmee; Appl. Microbiol. Biotechnol. 81, 1013 (2009) (Review) | (9) R. Mohamed, et al.; J. Pharm. Pharmacol. 66, 769 (2014) | (10) L. Zilbermintz, et al.; Sci. Rep. 6, 34846 (2016)