LY2835219
| Code | Size | Price |
|---|
| CDX-L0303-M100 | 100 mg | £194.00 |
Quantity:
| CDX-L0303-M250 | 250 mg | £353.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
LY2835219 methanesulfonate; Abemaciclib methanesulfonate; Abemaciclib mesylate; Bemaciclib
Appearance:
Off-white powder.
CAS:
1231930-82-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
InChiKey:
NCJPFQPEVDHJAZ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1231930-82-7. Formula: C27H32F2N8 . CH4O3S. MW: 602.7. LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
MDL:
MFCD25562906
Molecular Formula:
C27H32F2N8 . CH4O3S
Molecular Weight:
602.7
Package Type:
Vial
Precautions:
P261, P305+351+338, P302+352
Product Description:
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
Purity:
>99%
Signal word:
Warning
SMILES:
CCN(CC1)CCN1CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C(N=C(C)N5C(C)C)C5=C4)=N3)N=C2.CS(=O)(O)=O
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or water (30mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.
References
(1) M.A. Dickson; Clin. Cancer Res. 20, 3379 (2014) | (2) L.M. Gelbert, et al.; Invest. New. Drugs 32, 825 (2014) | (3) S.C. Tate, et al.; Clin. Cancer Res. 20, 3763 (2014)