D-Glucuronic acid
| Code | Size | Price |
|---|
| CDX-G0020-G025 | 25 g | £108.00 |
Quantity:
| CDX-G0020-G050 | 50 g | £157.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Glucosiduronic acid; D-GlcA
Appearance:
White to off-white powder.
CAS:
03/12/6556
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1
InChiKey:
AEMOLEFTQBMNLQ-QIUUJYRFSA-N
Long Description:
Chemical. CAS: 6556-12-3. Formula: C6H10O7. MW: 194.14. Glucuronic acid is a water soluble sugar acid formed by oxidation of the C-6 carbon of glucose. Glucuronic acid is a common building block of proteoglycans and glycoglycerolipids and a key intermediate metabolite of the uronic acid pathway. It can be used as a reference compound to quantify glucuronic acid in urine sample. It also has been shown to act on toll-like receptor 4 to aggravate both acute and chronic inflammatory conditions as well as increasing the perceived severity of pain in patients with chronic pain conditions, via up-regulation of the production and release of endogenous inflammatory signaling molecules within the body.
MDL:
MFCD00077778
Molecular Formula:
C6H10O7
Molecular Weight:
194.14
Package Type:
Vial
Product Description:
Glucuronic acid is a water soluble sugar acid formed by oxidation of the C-6 carbon of glucose. Glucuronic acid is a common building block of proteoglycans and glycoglycerolipids and a key intermediate metabolite of the uronic acid pathway. It can be used as a reference compound to quantify glucuronic acid in urine sample. It also has been shown to act on toll-like receptor 4 to aggravate both acute and chronic inflammatory conditions as well as increasing the perceived severity of pain in patients with chronic pain conditions, via up-regulation of the production and release of endogenous inflammatory signaling molecules within the body.
Purity:
>98% (HPLC)
SMILES:
O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1
Solubility Chemicals:
Soluble in water (50mg/ml) or DMSO (2mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) J.J. Burns, et al.; JPET 129, 132 (1960) | (2) T. Kishikawa, et al.; Chem. Pharm. Bull. 14, 1354 (1966) | (3) U. Lindahl, et al.; BBRC 46, 985 (1972) | (4) A.O. El-Nezhawy, et al.; Arch. Pharm. 344, 648 (2011) | (5) A.O. El-Nezhawy, et al.; Med. Chem. 7, 624 (2011) | (6) S.S. Lewis, et al.; Brain Behav. Immun. 30, 24 (2013) | (7) S. Marasini, et al.; J. Nanosci. Nanotechnol. 18, 6333 (2018)