TCEP
| Code | Size | Price |
|---|
| CDX-T0176-G002 | 2 g | £78.00 |
Quantity:
| CDX-T0176-G005 | 5 g | £145.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Tris(2-carboxyethyl)phosphine hydrochloride
Appearance:
White to off-white powder.
CAS:
51805-45-9
Class:
8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS05
Handling Advice:
Protect from light and moisture.
Hazards:
H314
InChi:
InChI=1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H
InChiKey:
PBVAJRFEEOIAGW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 51805-45-9. Formula: C9H15O6P?HCl. MW: 286.60. TCEP is an odorless, selective, and water-soluble strong reducing agent that is commonly used in biochemistry and molecular biology applications. It is commonly used to rapidly reduce protein and peptide disulfide bonds a preparatory step for gel electrophoresis. TCEP can be combined with proteases to simultaneously reduce and digest proteins prior to mass spectrometry in order to dramatically increase sequence coverage. More stable than DTT and useful in mass spectrometry applications. It has also been used to measure ascorbic acid and dehydroascorbic acid in biological samples. TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).
MDL:
MFCD00145469
Molecular Formula:
C9H15O6P . HCl
Molecular Weight:
286.6
Package Type:
Vial
PG:
II
Precautions:
P280-P305 + P351 + P338-P310
Product Description:
TCEP is an odorless, selective, and water-soluble strong reducing agent that is commonly used in biochemistry and molecular biology applications. It is commonly used to rapidly reduce protein and peptide disulfide bonds a preparatory step for gel electrophoresis. TCEP can be combined with proteases to simultaneously reduce and digest proteins prior to mass spectrometry in order to dramatically increase sequence coverage. More stable than DTT and useful in mass spectrometry applications. It has also been used to measure ascorbic acid and dehydroascorbic acid in biological samples. TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).
Purity:
>98% (NMR)
Signal word:
Danger
SMILES:
OC(CCP(CCC(O)=O)CCC(O)=O)=O.Cl
Solubility Chemicals:
Soluble in water (50mg/ml) or DMSO (3mg/ml).
Transportation:
Excepted Quantity
UN Nummer:
3261
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) J. Lykkesfeldt; Anal. Biochem. 282, 89 (2000) | (2) C.C. Visser, et al.; J. Drug Target 12, 569 (2004) | (3) C. David, et al.; Phys. Chem. Chem. Phys. 11, 2532 (2009) | (4) P. Liu, et al.; J. Am. Soc. Mass Spectrom. 21, 837 (2010) | (5) H.M. Zhang, et al.; Anal. Chem. 82, 1450 (2010)