Tadalafil
| Code | Size | Price |
|---|
| CDX-T0455-M050 | 50 mg | £78.00 |
Quantity:
| CDX-T0455-M500 | 500 mg | £437.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
GF196960; (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione
Appearance:
White to beige powder.
CAS:
171596-29-5
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315-H319-H335
InChi:
InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChiKey:
WOXKDUGGOYFFRN-IIBYNOLFSA-N
Long Description:
Chemical. CAS: 171596-29-5. Formula: C22H19N3O4. MW: 389.40. Tadalafil is a potent long-acting and selective inhibitor of the cGMP specific phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, benign prostatic hyperplasia (BPH) and lower urinary tract dysfunction. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression.
MDL:
MFCD07771966
Molecular Formula:
C22H19N3O4
Molecular Weight:
389.4
Package Type:
Vial
Precautions:
P305 + P351 + P338
Product Description:
Tadalafil is a potent long-acting and selective inhibitor of the cGMP specific phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, benign prostatic hyperplasia (BPH) and lower urinary tract dysfunction. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression.
Purity:
>98%
Signal word:
Warning
SMILES:
[H][C@@]12N(C(CN(C)C2=O)=O)[C@H](C3=CC=C(OCO4)C4=C3)C5=C(C(C=CC=C6)=C6N5)C1
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or DMF (25mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) A. Daugan, et al.; J. Med. Chem. 46, 4533 (2003) | (2) G.L. Card, et al.; Structure 12, 2233 (2004) | (3) P. Serafini, et al.; J. Exp. Med. 203, 2691 (2006) | (4) J. Kuan & G. Brock; Expert Opin. Investig. Drugs 11, 1605 (2002) (Review) | (5) R.A. Kloner, et al.; Am. J. Cardiol. 92, 37M (2003) (Review) | (6) S.A. Arif & H. Poon; Clin. Ther. 33, 993 (2011) (Review)