Repaglinide
| Code | Size | Price |
|---|
| CDX-R0122-M050 | 50 mg | £72.00 |
Quantity:
| CDX-R0122-M250 | 250 mg | £194.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +20°C, Long Term: +4°C
Documents
Further Information
Alternate Names/Synonyms:
(S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid; Novonorm; Prandin
Appearance:
White to off-white powder.
CAS:
135062-02-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
InChiKey:
FAEKWTJYAYMJKF-QHCPKHFHSA-N
Long Description:
Chemical. CAS: 135062-02-1. Formula: C27H36N2O4. MW: 452.59. Repaglinide is a metaglitinide antidiabetic agent. It is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes. Repaglinide shows also antioxidant and anti-inflammatory properties.
MDL:
MFCD00906179
Molecular Formula:
C27H36N2O4
Molecular Weight:
452.59
Package Type:
Vial
Product Description:
Repaglinide is a metaglitinide antidiabetic agent. It is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes. Repaglinide shows also antioxidant and anti-inflammatory properties.
Purity:
>98% (HPLC)
SMILES:
O=C(CC1=CC(OCC)=C(C(O)=O)C=C1)N[C@@H](CC(C)C)C2=CC=CC=C2N3CCCCC3
Solubility Chemicals:
Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (20mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) B.H. Wolffenbuttel, et al.; Eur. J. Clin. Pharmacol. 45, 113 (1993) | (2) J. Gromada, et al.; Diabetologia 38, 1025 (1995) | (3) D.R. Owens; Eur. J. Clin. Invest. 29, 30 (1999) (Review) | (4) V. Ambavane, et al.; J. Postgrad. Med. 48, 246 (2002) (Review) | (5) A.M. Hansen, et al.; Br. J. Pharmacol. 144, 551 (2005) | (6) A. Gumieniczek, et al.; Pharmacol. Res. 52, 162 (2005) | (7) D. Tung, et al.; Pharmacology 88, 295 (2011) | (8) P. Kuhner, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 385, 299 (2012) | (9) L.J. Scott; Drugs 72, 249 (2012) (Review) | (10) D. Ding, et al.; Cell Rep. 27, 1848 (2019)